General process of Preimplantation Genetic Testing

General process of Preimplantation Genetic Testing

Preimplantation Genetic Testing (PGT) is a laboratory procedure used in conjunction with in vitro fertilization (IVF) to screen embryos for genetic abnormalities before they are implanted into the uterus. PGT helps identify embryos with chromosomal abnormalities, genetic disorders, or specific gene mutations, allowing for the selection of embryos that are more likely to result in a healthy pregnancy. For more information you can consult IVF Centre in Punjab. There are different types of PGT, each serving a specific purpose:

  • PGT-A (Aneuploidy Testing):
    • PGT-A is used to identify numerical chromosomal abnormalities, such as aneuploidy. Aneuploidy refers to an abnormal number of chromosomes, which can lead to conditions like Down syndrome. PGT-A helps select embryos with the correct number of chromosomes for implantation.
  • PGT-M (Monogenic/Single Gene Disorders Testing):
    • PGT-M is employed when one or both parents carry a known genetic mutation that could be passed on to their offspring. This testing allows for the identification of embryos that are free from the specific genetic disorder.
  • PGT-SR (Structural Rearrangement Testing):
    • PGT-SR is used when one or both parents have structural chromosomal rearrangements, such as translocations or inversions. This testing helps identify embryos with a normal chromosomal structure. Consult the Best IVF Centre in Jalandhar.

The PGT process typically involves the following steps:

  1. Ovulation Induction and Egg Retrieval:The woman undergoes ovarian stimulation to produce multiple eggs. Once the eggs are mature, they are retrieved from the ovaries.
  2. In Vitro Fertilization (IVF):The retrieved eggs are fertilized with sperm in a laboratory, resulting in the formation of embryos.
  3. Embryo Culture:The embryos are cultured in the laboratory for a few days, allowing them to develop.
  4. Cell Biopsy:A few cells are removed from each embryo at the blastocyst stage (around day 5 or 6 of development).
  5. Genetic Testing:The removed cells are subjected to genetic testing based on the specific type of PGT being performed (PGT-A, PGT-M, or PGT-SR).
  6. Embryo Selection:The embryos that are identified as genetically normal are selected for transfer to the uterus.
  7. Embryo Transfer:One or more healthy embryos are transferred to the woman’s uterus for implantation.

Success rate of the PGT: The success rate of the PGT (Preimplantation Genetic Testing) procedure can vary depending on several factors, such as the specific genetic condition being tested for, the age of the woman undergoing the procedure, and the expertise of the medical team performing it. Generally, PGT has been found to have a high accuracy rate in detecting genetic abnormalities in embryos, which can increase the chances of a successful pregnancy and healthy baby. However, it’s best to consult with a medical professional who can provide more specific information based on individual circumstances such as  Best IVF Centre in Jalandhar.

PGT aims to improve the chances of a successful pregnancy and reduce the risk of miscarriage by selecting embryos with a higher likelihood of developing into healthy pregnancies. It is often recommended for couples with a history of genetic disorders, advanced maternal age, or repeated pregnancy losses. However, it is important to note that PGT is not a guarantee of a successful pregnancy, and ethical considerations surround the use of this technology.