Endometriosis is a chronic inflammatory condition that affects the women reproductive period. Eventually, this problem affects fertility and it also causes pelvic pain. The studies have shown that this negatively impacts ovarian physiology. Additionally, there is no comprehensive evaluation of the effect of endometriosis on oocyte quality and the research is still going on to effectively treat the issue.
Based on the systematic review of the literature, it reviewed that women who are facing this issue while getting the treatment of In-Vitro-maturation and it might lead to another issue of infertility. Moreover, the results from IVF also showed that there is a reduction in the number of mature oocytes because of endometriosis.
The relation between Oocyte quality and Endometriosis
Studies indicate that it is associated with certain inflammatory substances such as
- Macrophages: The type of white blood cell which helps in eliminating cellular debris and foreign organisms.
- Cytokines: It promotes inflammation in response to your body’s own immune system.
Due to these inflammatory substances can affect the oocyte quality because they are highly toxic to the eggs. In addition to this, one report showed that women with a high level of endometriosis of these substances and lower chances of pregnancy suggest that “embryo quality is affected because of endometriosis-related toxic substances”.
Due to this, it also increases the chances of miscarriage or some other issue related to fertility.
Risk
Women facing the issue of endometriosis are at high risk of early pregnancy loss (miscarriage) and it affects the embryo quality. The connection between the endometriosis and egg quality has one basic explanation.
For egg maturation, there are two important reproductive hormones which the ovaries produce which are progesterone and estrogen. Research showed that when there is a hormonal imbalance in the ovaries due to endometriosis condition it can affect the development of egg and egg (oocyte) quality. Not only this, but it also decreases the egg count which will result in infertility. So, women with endometriosis have fewer eggs around the ovarian tissue.
Affects blood flow
Another thing which is affected because of the relation between endometriosis and egg quality is the scar tissue which is present in the women’s reproductive tract. The ovaries will get less oxygen because the scar tissue contains blood flow within the ovaries. If the eggs are not getting proper oxygen they will not get mature properly and this will affect the process of fertilization, implant, and development of the oocyte.
oocyte cryopreservation
Oocyte cryopreservation (egg freezing) is one of the best options for women who are facing the issue of endometriosis. This means it will solve the problem of both egg quality and egg quantity which will be related to endometriosis.
With this method, the women can preserve their eggs for future use and when she is ready the eggs will be thawed and will put in the ovaries. So this is a great option to preserve fertility and ovarian reserve because of an issue. You should consult the doctor from best IVF center in India.